Results from the MR CLEAN Registry: EVT in anterior circulation stroke beyond 6.5 hours after onset

In a MR CLEAN Registry study on 106 late window LVO patients, EVT showed similar functional and safety outcomes as in the early window. The majority of patients were not selected based on CTP but on favorable clinical and CT/CTA characteristics. More inclusive randomized trials are needed to expand the benefit of EVT in late window stroke patients.

Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well: results from the MR CLEAN Registry

Luuk Dekker, Esmee Venema, F Anne V Pirson, Charles B L M Majoie, Bart J Emmer, Ivo G H Jansen, Maxim J H L Mulder, Robin Lemmens, Robert-Jan B Goldhoorn, Marieke J H Wermer, Jelis Boiten, Geert J Lycklama À Nijeholt, Yvo B W E M Roos, Adriaan C G M van Es, Hester F Lingsma, Diederik W J Dippel, Wim H van Zwam, Robert J van Oostenbrugge, Ido R van den Wijngaard, MR CLEAN Registry investigators

Abstract

Background: Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment (EVT) for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well. However, outcomes after EVT in these late window patients without perfusion imaging are largely unknown. We assessed their characteristics and outcomes in routine clinical practice.

Methods: The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry, a prospective, multicentre study in the Netherlands, included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017. CT perfusion was no standard imaging modality. We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age, prestroke modified Rankin Scale (mRS), National Institutes of Health Stroke Scale, Alberta Stroke Programme Early CT Score (ASPECTS), collateral status, location of occlusion and treatment with intravenous thrombolysis. Outcomes included 3-month mRS score, functional independence (defined as mRS 0-2), and death.

Results: Of 3264 patients who underwent EVT, 106 (3.2%) were treated beyond 6.5 hours (median 8.5, IQR 6.9-10.6), of whom 93 (87.7%) had unknown time of stroke onset. CT perfusion was not performed in 87/106 (80.2%) late window patients. Late window patients were younger (mean 67 vs 70 years, p<0.04) and had slightly lower ASPECTS (median 8 vs 9, p<0.01), but better collateral status (collateral score 2-3: 68.3% vs 57.7%, p=0.03). No differences were observed in proportions of functional independence (43.3% vs 40.5%, p=0.57) or death (24.0% vs 28.9%, p=0.28). After matching, outcomes remained similar (adjusted common OR for 1 point improvement in mRS 1.04, 95% CI 0.56 to 1.93).

Conclusions: Without the use of CT perfusion selection criteria, EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics. randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window.

Reference to paper: 

Dekker L, Venema E, Pirson FAV, Majoie CBLM, Emmer BJ, Jansen IGH, Mulder MJHL, Lemmens R, Goldhoorn RB, Wermer MJH, Boiten J, Lycklama À Nijeholt GJ, Roos YBWEM, van Es ACGM, Lingsma HF, Dippel DWJ, van Zwam WH, van Oostenbrugge RJ, van den Wijngaard IR; MR CLEAN Registry investigators. Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well: results from the MR CLEAN Registry. Stroke Vasc Neurol. 2021 Apr 7:svn-2020-000803. doi: 10.1136/svn-2020-000803. Epub ahead of print. PMID: 33827915.

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